Spurs welcome back the Belgian as the club looks to maintain their 100% record.
Tottenham Hotspur host Swansea City in the second Premier League match of the season for these two sides, with Spurs looking to build on a 1-0 win at Crystal Palace last weekend.
Jan Vertonghen will partner captain Michael Dawson at the back and looks to have fully recovered from injury, whilst after impressing in the Europa League mid-week Andros Townsend makes a league start for the first time.
Club record signing Wilfried Bony is once again on the bench for Swansea as the Welsh side look to bounce back from an opening day defeat to Manchester United.
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